In-silico design and evaluation of an epitope-based serotype-independent promising vaccine candidate for highly cross-reactive regions of pneumococcal surface protein A

In-silico design and evaluation of an epitope-based serotype-independent promising vaccine candidate for highly cross-reactive regions of pneumococcal surface protein A

Abstract Background The pathogenicity of pneumococcus with high morbidity, mortality, and multi-drug resistance patterns has been increasing. The limited coverage of the licensed polysaccharide-based vaccines and the replacement of the non-vaccine serotypes are the main reasons for producing a succe...

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Bibliographic Details
Main Authors: Elnaz Afshari, Reza Ahangari Cohan, Fattah Sotoodehnejadnematalahi, Seyed Fazlollah Mousavi
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Journal of Translational Medicine
Subjects:
Clade-defining region
Cross-reactivity
PspA
Serotype-independent vaccine
Streptococcus pneumoniae
Immunoinformatics
Online Access:https://doi.org/10.1186/s12967-022-03864-z

Internet

https://doi.org/10.1186/s12967-022-03864-z

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