Effectiveness of two different dose administration regimens of an IL-15 superagonist complex (ALT-803) in an orthotopic bladder cancer mouse model

Effectiveness of two different dose administration regimens of an IL-15 superagonist complex (ALT-803) in an orthotopic bladder cancer mouse model

Abstract Background We set out to determine if the administration of subcutaneous (SQ) ALT-803 was non-inferior to standard intravesical BCG treatment in a carcinogen induced mouse (C57BL/6J) bladder cancer model. Methods Using this well-established carcinogen induced mouse model, we studied the eff...

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Bibliographic Details
Main Authors: Hideki Furuya, Owen T. M. Chan, Ian Pagano, Chengjun Zhu, Nari Kim, Rafael Peres, Kanani Hokutan, Sarah Alter, Peter Rhode, Charles J. Rosser
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Journal of Translational Medicine
Subjects:
Bladder cancer
Treatment
BCG
IL-15
ALT-803
Online Access:http://link.springer.com/article/10.1186/s12967-019-1778-6

Internet

http://link.springer.com/article/10.1186/s12967-019-1778-6

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