Molecular Dissection of a Conserved Cluster of miRNAs Identifies Critical Structural Determinants That Mediate Differential Processing

Molecular Dissection of a Conserved Cluster of miRNAs Identifies Critical Structural Determinants That Mediate Differential Processing

Differential processing is a hallmark of clustered microRNAs (miRNAs) and the role of position and order of miRNAs in a cluster together with the contribution of stem-base and terminal loops has not been explored extensively within the context of a polycistronic transcript. To elucidate the structur...

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Bibliographic Details
Main Authors: Manish Pandey, Arthur Luhur, Nicholas S. Sokol, Geetanjali Chawla
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
miRNA
terminal loop
stem-base
polycistronic
Drosha
Dicer
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.909212/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.909212/full

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