The glycosyltransferase EXTL2 promotes proteoglycan deposition and injurious neuroinflammation following demyelination

The glycosyltransferase EXTL2 promotes proteoglycan deposition and injurious neuroinflammation following demyelination

Abstract Background Chondroitin sulfate proteoglycans (CSPGs) are potent inhibitors of axonal regrowth and remyelination. More recently, they have also been highlighted as a modulator of macrophage infiltration into the central nervous system in experimental autoimmune encephalomyelitis, an inflamma...

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Bibliographic Details
Main Authors: Annie Pu, Manoj K. Mishra, Yifei Dong, Samira Ghorbanigazar, Erin L. Stephenson, Khalil S. Rawji, Claudia Silva, Hiroshi Kitagawa, Stephen Sawcer, V. Wee Yong
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Journal of Neuroinflammation
Subjects:
CSPG
Multiple sclerosis
Inflammation
Demyelination
Oligodendrocyte
EXTL2
Online Access:http://link.springer.com/article/10.1186/s12974-020-01895-1

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http://link.springer.com/article/10.1186/s12974-020-01895-1

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