Elucidating the changes in the heterogeneity and function of radiation-induced cardiac macrophages using single-cell RNA sequencing

Elucidating the changes in the heterogeneity and function of radiation-induced cardiac macrophages using single-cell RNA sequencing

PurposeA mouse model of irradiation (IR)-induced heart injury was established to investigate the early changes in cardiac function after radiation and the role of cardiac macrophages in this process.MethodsCardiac function was evaluated by heart-to-tibia ratio, lung-to-heart ratio and echocardiograp...

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Bibliographic Details
Main Authors: Chunxiang Cao, Ran Wu, Shubei Wang, Lingfang Zhuang, Peizhan Chen, Shuyan Li, Qian Zhu, Huan Li, Yingying Lin, Min Li, Lu Cao, Jiayi Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Immunology
Subjects:
macrophage
irradiation
heart injury
single-cell RNA sequencing
senescence
interferon
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1363278/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1363278/full

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