Alcohol and Liver Clock Disruption Increase Small Droplet Macrosteatosis, Alter Lipid Metabolism and Clock Gene mRNA Rhythms, and Remodel the Triglyceride Lipidome in Mouse Liver

Alcohol and Liver Clock Disruption Increase Small Droplet Macrosteatosis, Alter Lipid Metabolism and Clock Gene mRNA Rhythms, and Remodel the Triglyceride Lipidome in Mouse Liver

Heavy alcohol drinking dysregulates lipid metabolism, promoting hepatic steatosis – the first stage of alcohol-related liver disease (ALD). The molecular circadian clock plays a major role in synchronizing daily rhythms in behavior and metabolism and clock disruption can cause pathology, including l...

Full description

Bibliographic Details
Main Authors: Jennifer A. Valcin, Uduak S. Udoh, Telisha M. Swain, Kelly K. Andringa, Chirag R. Patel, Sameer Al Diffalha, Paul R. S. Baker, Karen L. Gamble, Shannon M. Bailey
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Physiology
Subjects:
liver
alcohol
circadian clock
BMAL1
steatosis
triglyceride
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.01048/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2020.01048/full

Similar Items