Tumor suppressor OTUD3 induces growth inhibition and apoptosis by directly deubiquitinating and stabilizing p53 in invasive breast carcinoma cells

Tumor suppressor OTUD3 induces growth inhibition and apoptosis by directly deubiquitinating and stabilizing p53 in invasive breast carcinoma cells

Abstract Background P53 pathway inactivation plays an important role in the process of breast cancer tumorigenesis. Post-translational protein modification abnormalities have been confirmed to be an important mechanism underlying inactivation of p53. Numerous deubiquitinating enzymes are aberrantly...

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Bibliographic Details
Main Authors: Qian Pu, Yan-rong Lv, Ke Dong, Wen-wen Geng, Hai-dong Gao
Format: Article
Language:English
Published: BMC 2020-06-01
Series:BMC Cancer
Subjects:
OTUD3
p53
Deubiquitinating enzymes
Invasive breast carcinoma
Online Access:http://link.springer.com/article/10.1186/s12885-020-07069-9

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http://link.springer.com/article/10.1186/s12885-020-07069-9

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