Bispecific T cell-engager targeting oncofetal chondroitin sulfate induces complete tumor regression and protective immune memory in mice

Bispecific T cell-engager targeting oncofetal chondroitin sulfate induces complete tumor regression and protective immune memory in mice

Abstract Background The malaria protein VAR2CSA binds oncofetal chondroitin sulfate (ofCS), a unique chondroitin sulfate, expressed on almost all mammalian cancer cells. Previously, we produced a bispecific construct targeting ofCS and human T cells based on VAR2CSA and anti-CD3 (V-aCD3Hu). V-aCD3Hu...

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Bibliographic Details
Main Authors: Nanna Skeltved, Mie A. Nordmaj, Nicolai T. Berendtsen, Robert Dagil, Emilie M. R. Stormer, Nader Al-Nakouzi, Ke Jiang, Alexandra Aicher, Christopher Heeschen, Tobias Gustavsson, Swati Choudhary, Ismail Gögenur, Jan P. Christensen, Thor G. Theander, Mads Daugaard, Ali Salanti, Morten A. Nielsen
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Immunotherapy
Cancer
Bispecific antibodies
Targeted therapy
VAR2CSA
Checkpoint inhibitor
Online Access:https://doi.org/10.1186/s13046-023-02655-8

Internet

https://doi.org/10.1186/s13046-023-02655-8

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