Apelin is expressed in intimal smooth muscle cells and promotes their phenotypic transition

Apelin is expressed in intimal smooth muscle cells and promotes their phenotypic transition

Abstract During atherosclerotic plaque formation, smooth muscle cells (SMCs) switch from a contractile/differentiated to a synthetic/dedifferentiated phenotype. We previously isolated differentiated spindle-shaped (S) and dedifferentiated rhomboid (R) SMCs from porcine coronary artery. R-SMCs expres...

Full description

Bibliographic Details
Main Authors:	Luís Miguel Cardoso Dos Santos, Pascal Azar, Cécile Brun, Stéphane König, Angela Roatti, Alex J. Baertschi, Chiraz Chaabane, Marie-Luce Bochaton-Piallat
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-10-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-023-45470-z

Similar Items

Apelin attenuates the osteoblastic differentiation of vascular smooth muscle cells.
by: Peng-Fei Shan, et al.
Published: (2011-03-01)

Vascular smooth muscle cells in intimal hyperplasia, an update
by: Sébastien Déglise, et al.
Published: (2023-01-01)

The role of 6-phosphogluconate dehydrogenase in vascular smooth muscle cell phenotypic switching and angioplasty-induced intimal hyperplasia
by: Amy L. Lu, et al.
Published: (2024-01-01)

The Etiology and Molecular Mechanism Underlying Smooth Muscle Phenotype Switching in Intimal Hyperplasia of Vein Graft and the Regulatory Role of microRNAs
by: Dengshen Zhang, et al.
Published: (2022-07-01)

Effect of L-Carnitine Supplementation on Apelin and Apelin Receptor (Apj) Expression in Cardiac Muscle of Obese Diabetic Rats
by: neda Ranjbar Kohan, et al.
Published: (2018-06-01)

On Methods for the Measurement of the Apelin Receptor Ligand Apelin
by: Peter Janssens, et al.
Published: (2022-05-01)

Tripeptide Arg-Gly-Asp (RGD) modifies the molecular mechanical properties of the non-muscle myosin IIA in human bone marrow-derived myofibroblasts seeded in a collagen scaffold.
by: Yves Lecarpentier, et al.
Published: (2019-01-01)

APELIN-12 AND APELIN-36 IN SPUTUM OF PATIENTS WITH BRONCHIAL ASTHMA
by: V. N. Mineev, et al.
Published: (2017-06-01)

Statistical Mechanics of Non-Muscle Myosin IIA in Human Bone Marrow-Derived Mesenchymal Stromal Cells Seeded in a Collagen Scaffold: A Thermodynamic Near-Equilibrium Linear System Modified by the Tripeptide Arg-Gly-Asp (RGD)
by: Yves Lecarpentier, et al.
Published: (2020-06-01)

Vascular smooth muscle cell phenotypic switching in atherosclerosis
by: Yanqiao Yu, et al.
Published: (2024-09-01)

Phenotypic Switching of Vascular Smooth Muscle Cells in Atherosclerosis
by: Runji Chen, et al.
Published: (2023-10-01)

Nitric Oxide Production and Smooth Muscle Cell Phenotype of Endothelial Cell-Smooth Muscle Cell Cocultured Model
by: Naoya SAKAMOTO, et al.
Published: (2006-10-01)

The Effects of Apelin and Elabela Ligands on Apelin Receptor Distinct Signaling Profiles
by: Yunlu Jiang, et al.
Published: (2021-03-01)

Proteoglycan 4 Modulates Osteogenic Smooth Muscle Cell Differentiation during Vascular Remodeling and Intimal Calcification
by: Till Seime, et al.
Published: (2021-05-01)

PLF‐1 (Proliferin‐1) Modulates Smooth Muscle Cell Proliferation and Development of Experimental Intimal Hyperplasia
by: Lina Hu, et al.
Published: (2019-12-01)

Apelin and energy metabolism
by: Chantal eBertrand, et al.
Published: (2015-04-01)

Syndecan-1 regulates vascular smooth muscle cell phenotype.
by: Somali Chaterji, et al.
Published: (2014-01-01)

Vascular Smooth Muscle Cells Phenotypic Switching in Cardiovascular Diseases
by: Hao-Yue Tang, et al.
Published: (2022-12-01)

Characterization of Carotid Smooth Muscle Cells during Phenotypic Transition
by: Haize Goikuria, et al.
Published: (2018-03-01)

Vascular smooth muscle cell phenotype switching in carotid atherosclerosis
by: Elizabeth L. Chou, MD, et al.
Published: (2022-01-01)

Vascular smooth muscle cell phenotypic modulation and the extracellular matrix
by: Maryam Heidari, et al.
Published: (2015-01-01)

Phenotypic Reversion of Smooth Muscle Cells in Hybrid Vascular Prostheses
by: Keiichi Kanda, et al.
Published: (1995-11-01)

Targeting smooth muscle cell phenotypic switching in vascular disease
by: Raja Chakraborty, PhD, et al.
Published: (2021-01-01)

Cigarette smoke modulates vascular smooth muscle phenotype: implications for carotid and cerebrovascular disease.
by: Robert M Starke, et al.
Published: (2013-01-01)

Targeting the elabela/apelin-apelin receptor axis as a novel therapeutic approach for hypertension
by: Jiawei Song, et al.
Published: (2022-05-01)

SRF SUMOylation modulates smooth muscle phenotypic switch and vascular remodeling
by: Yue Xu, et al.
Published: (2024-08-01)

Spaceflight effects on human vascular smooth muscle cell phenotype and function
by: Marina M. Scotti, et al.
Published: (2024-03-01)

Caveolin-3 promotes a vascular smooth muscle contractile phenotype
by: Jorge L. Gutierrez-Pajares, et al.
Published: (2015-06-01)

Role of dystrophin in airway smooth muscle phenotype, contraction and lung function.
by: Pawan Sharma, et al.
Published: (2014-01-01)

The Phenotypic Responses of Vascular Smooth Muscle Cells Exposed to Mechanical Cues
by: Lise Filt Jensen, et al.
Published: (2021-08-01)

Circulating apelin levels fail to link sarcopenia-related muscle parameters in older adults
by: Eunhye Ji, et al.
Published: (2025-03-01)

Apelin and its Receptor: An Overview
by: Rajeev Gandham, et al.
Published: (2019-06-01)

Effects of Apelin on Cardiovascular Aging
by: Ying Zhou, et al.
Published: (2017-12-01)

Apelin-13 inhibits large-conductance Ca2+-activated K+ channels in cerebral artery smooth muscle cells via a PI3-kinase dependent mechanism.
by: Amit Modgil, et al.
Published: (2013-01-01)

A Tead1-Apelin axis directs paracrine communication from myogenic to endothelial cells in skeletal muscle
by: Umji Lee, et al.
Published: (2022-07-01)

The Role of Apelin/Apelin Receptor in Energy Metabolism and Water Homeostasis: A Comprehensive Narrative Review
by: Gonghui Hu, et al.
Published: (2021-02-01)

Knockdown of ARHGAP24 reduces intimal hyperplasia through inhibiting the proliferation and phenotypic switching of smooth muscle cells possibly by inactivating both AKT and ERK1/2 signaling pathways
by: Wei Liu, et al.
Published: (2024-03-01)

Endothelial‐Smooth Muscle Cell Interactions in a Shear‐Exposed Intimal Hyperplasia on‐a‐Dish Model to Evaluate Therapeutic Strategies
by: Andreia Fernandes, et al.
Published: (2022-10-01)

A Human Pluripotent Stem Cell-Based Screen for Smooth Muscle Cell Differentiation and Maturation Identifies Inhibitors of Intimal Hyperplasia
by: Jue Zhang, et al.
Published: (2019-06-01)

Role of the Vasopressin/Apelin Balance and Potential Use of Metabolically Stable Apelin Analogs in Water Metabolism Disorders
by: Adrien Flahault, et al.
Published: (2017-05-01)