Transcriptional repression and cell death induced by nuclear aggregates of non-polyglutamine protein

Transcriptional repression and cell death induced by nuclear aggregates of non-polyglutamine protein

Nuclear aggregates of polyglutamine (polyQ)-expanded proteins are associated with a number of neurodegenerative diseases including Huntington's disease (HD) and spinocerebellar ataxias (SCAs). The nuclear deposition of polyQ proteins correlates with rearrangements of nuclear matrix, transcripti...

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Bibliographic Details
Main Authors: Lianwu Fu, Ya-sheng Gao, Elizabeth Sztul
Format: Article
Language:English
Published: Elsevier 2005-12-01
Series:Neurobiology of Disease
Subjects:
Nuclear aggregates
Nuclear inclusions
Polyglutamine
Huntingtin
Ataxin
CBP
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996105001348

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http://www.sciencedirect.com/science/article/pii/S0969996105001348

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