Phase-separated CCER1 coordinates the histone-to-protamine transition and male fertility

Phase-separated CCER1 coordinates the histone-to-protamine transition and male fertility

Abstract Idiopathic fertility disorders are associated with mutations in various genes. Here, we report that coiled-coil glutamate-rich protein 1 (CCER1), a germline-specific and intrinsically disordered protein (IDP), mediates postmeiotic spermatid differentiation. In contrast, CCER1 deficiency res...

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Bibliographic Details
Main Authors: Dongdong Qin, Yayun Gu, Yu Zhang, Shu Wang, Tao Jiang, Yao Wang, Cheng Wang, Chang Chen, Tao Zhang, Weiya Xu, Hanben Wang, Ke Zhang, Liangjun Hu, Lufan Li, Wei Xie, Xin Wu, Zhibin Hu
Format: Article
Language:English
Published: Nature Portfolio 2023-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-43480-z

Internet

https://doi.org/10.1038/s41467-023-43480-z

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