Comparative analysis of response to treatments and molecular features of tumor-derived organoids versus cell lines and PDX derived from the same ovarian clear cell carcinoma

Comparative analysis of response to treatments and molecular features of tumor-derived organoids versus cell lines and PDX derived from the same ovarian clear cell carcinoma

Abstract Background In the era of personalized medicine, the establishment of preclinical models of cancer that faithfully recapitulate original tumors is essential to potentially guide clinical decisions. Methods We established 7 models [4 cell lines, 2 Patient-Derived Tumor Organoids (PDTO) and 1...

Full description

Bibliographic Details
Main Authors: Lucie Thorel, Pierre-Marie Morice, Hippolyte Paysant, Romane Florent, Guillaume Babin, Cécilia Thomine, Marion Perréard, Edwige Abeilard, Florence Giffard, Emilie Brotin, Christophe Denoyelle, Céline Villenet, Shéhérazade Sebda, Mélanie Briand, Florence Joly, Enora Dolivet, Didier Goux, Cécile Blanc-Fournier, Corinne Jeanne, Marie Villedieu, Matthieu Meryet-Figuiere, Martin Figeac, Laurent Poulain, Louis-Bastien Weiswald
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Ovarian clear cell carcinoma
Patient-derived tumor organoids
Patient-derived xenograft
Patient-derived cell lines
Precision medicine
Predictive functional assays
Online Access:https://doi.org/10.1186/s13046-023-02809-8

Internet

https://doi.org/10.1186/s13046-023-02809-8

Similar Items