Exercise promotes motor functional recovery in rats with corticospinal tract injury: anti-apoptosis mechanism

Studies have shown that exercise interventions can improve functional recovery after spinal cord injury, but the mechanism of action remains unclear. To investigate the mechanism, we established a unilateral corticospinal tract injury model in rats by pyramidotomy, and used a single pellet reaching...

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Bibliographic Details
Main Authors:	Ting-ting Hou, Xiao-yu Yang, Peng Xia, Su Pan, Jian Liu, Zhi-ping Qi
Format:	Article
Language:	English
Published:	Wolters Kluwer Medknow Publications 2015-01-01
Series:	Neural Regeneration Research
Subjects:	spinal cord injury propriospinal system neural plasticity fiber sprouting neural repair compensation regeneration propriospinal detours neurotrophic factors cell-adhesive ligands dorsal root ganglia L1CAM nerve growth factor biomaterials elastin-like proteins Alzheimer′s disease AMPK apoptosis autophagy central nervous system CCN4 EGF diabetes mellitus erythropoietin EPO FGF IGF-1 mTOR neuron neuropathy oxidative stress psychiatric stem cells WISP1 Wnt peripheral nerve injury nerve graft nerve conduit Wallerian degeneration veins autografts nerve regeneration neuroprotection resveratrol cerebral ischemia cerebral infarction matrix metalloproteinase molecular docking extracellular matrix neural regeneration vagus nerve stimulation inflammatory cytokines infarct volume neurological function NSFC grants Xingnao Kaiqiao needling method ischemic stroke randomized controlled trial systemic reviews meta-analysis long-term efficacy mortality recurrence disability adverse reactions health economics indicators DDPH hippocampus blood flow isolated basilar artery dose-response curve NSFC grant traumatic brain injury coma median nerve electrical stimulation wake-promoting orexin-A OX1R seizure antiepileptic drugs immature brain synaptic plasticity glutamate receptor puerarin in vitro experiments co-culture neurons astrocytes Transwell neonatal rats brain injury inflammatory reaction interleukin-6 voltage-gated Na + channel cortical neurons cerebrospinal fluid neuroimmunomodulation action potential patch clamp neurophysiology cognition disorders diagnostic techniques Wechsler Intelligence Scale event-related potential neuronal plasticity electrophysiology neuropsychology activity of daily living work capacity evaluation electroencephalogram cerebral palsy corticospinal tract diffusion tensor hemiplegia motor rehabilitation matrix metalloproteinase 9 cervical and intracranial angioplasty and stenting restenosis intracranial artery stenosis bone marrow mesenchymal stem cells propofol cell transplantation motor function exercise functional recovery Bcl-2 Bax caspase-3
Online Access:	http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=4;spage=644;epage=650;aulast=Hou

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=4;spage=644;epage=650;aulast=Hou

Exercise promotes motor functional recovery in rats with corticospinal tract injury: anti-apoptosis mechanism

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