Effective and persistent antitumor activity of HER2-directed CAR-T cells against gastric cancer cells in vitro and xenotransplanted tumors in vivo
Abstract Human epidermal growth factor receptor 2 (HER2) proteins are overexpressed in a high proportion of gastric cancer (GC) cases and affect the maintenance of cancer stem cell (CSC) subpopulations, which are used as targets for the clinical treatment of patients with HER2-positive GC. Despite i...
Main Authors: | , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Oxford University Press
2017-03-01
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Series: | Protein & Cell |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1007/s13238-017-0384-8 |