Tumor microenvironment-responsive DNA-based nanomedicine triggers innate sensing for enhanced immunotherapy

Tumor microenvironment-responsive DNA-based nanomedicine triggers innate sensing for enhanced immunotherapy

Abstract Lack of proper innate sensing inside the tumor microenvironment could reduce both innate and adaptive immunity, which remains a critical cause of immunotherapy failure in various tumor treatments. Double-stranded DNA (dsDNA) has been evidenced to be a promising immunostimulatory agent to in...

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Bibliographic Details
Main Authors: Jinyang Li, Xiaoyu Han, Shanshan Gao, Yumeng Yan, Xiaoguang Li, Hui Wang
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Journal of Nanobiotechnology
Subjects:
Innate sensing
Tumor immunotherapy
Type I interferon
Immune checkpoint blockade
Nanomedicine
Online Access:https://doi.org/10.1186/s12951-023-02132-6

Internet

https://doi.org/10.1186/s12951-023-02132-6

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