IL-1β suppresses cLTP-induced surface expression of GluA1 and actin polymerization via ceramide-mediated Src activation

IL-1β suppresses cLTP-induced surface expression of GluA1 and actin polymerization via ceramide-mediated Src activation

Abstract Background Brain inflammation including increases in inflammatory cytokines such as IL-1β is widely believed to contribute to the pathophysiology of Alzheimer’s disease. Although IL-1β-induced impairments in long-term potentiation (LTP) in acute hippocampal slices and memory functions in vi...

Full description

Bibliographic Details
Main Authors: Liqi Tong, G. Aleph Prieto, Carl W. Cotman
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Journal of Neuroinflammation
Subjects:
IL-1β
Synaptic plasticity
Dendritic spine
GluA1
Actin dynamics
Online Access:http://link.springer.com/article/10.1186/s12974-018-1158-9

Internet

http://link.springer.com/article/10.1186/s12974-018-1158-9

Similar Items