Alternative RNA splicing in the endothelium mediated in part by Rbfox2 regulates the arterial response to low flow

Alternative RNA splicing in the endothelium mediated in part by Rbfox2 regulates the arterial response to low flow

Low and disturbed blood flow drives the progression of arterial diseases including atherosclerosis and aneurysms. The endothelial response to flow and its interactions with recruited platelets and leukocytes determine disease progression. Here, we report widespread changes in alternative splicing of...

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Bibliographic Details
Main Authors: Patrick A Murphy, Vincent L Butty, Paul L Boutz, Shahinoor Begum, Amy L Kimble, Phillip A Sharp, Christopher B Burge, Richard O Hynes
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-01-01
Series:eLife
Subjects:
alternative splicing
endothelial
vascular
platelet
Atherosclerosis
artery
Online Access:https://elifesciences.org/articles/29494

Internet

https://elifesciences.org/articles/29494

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