Proteoform Analysis of Matrix Metalloproteinase-9/Gelatinase B and Discovery of Its Citrullination in Rheumatoid Arthritis Synovial Fluids

Proteoform Analysis of Matrix Metalloproteinase-9/Gelatinase B and Discovery of Its Citrullination in Rheumatoid Arthritis Synovial Fluids

ObjectivesTo explore posttranslational modifications (PTMs), including proteolytic activation, multimerization, complex formation and citrullination of gelatinases, in particular of gelatinase B/MMP-9, and to detect in gelatin-Sepharose affinity-purified synovial fluids, the presence of specific MMP...

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Bibliographic Details
Main Authors: Bernard Grillet, Karen Yu, Estefania Ugarte-Berzal, Rik Janssens, Rafaela Vaz Sousa Pereira, Lise Boon, Erik Martens, Nele Berghmans, Isabelle Ronsse, Ilse Van Aelst, Pierre Fiten, René Conings, Jennifer Vandooren, Patrick Verschueren, Jo Van Damme, Paul Proost, Ghislain Opdenakker
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Immunology
Subjects:
matrix metalloproteinase
arthritis
proteoform
proteolysis
citrullination
synovial fluid
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.763832/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.763832/full

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