Synthesis of Unexpected Dimethyl 2-(4-Chlorophenyl)-2,3-dihydropyrrolo[2,1-<em>a</em>]isoquinoline-1,3-dicarboxylate via Hydrolysis/Cycloaddition/Elimination Cascades: Single Crystal X-ray and Chemical Structure Insights

Synthesis of Unexpected Dimethyl 2-(4-Chlorophenyl)-2,3-dihydropyrrolo[2,1-<em>a</em>]isoquinoline-1,3-dicarboxylate via Hydrolysis/Cycloaddition/Elimination Cascades: Single Crystal X-ray and Chemical Structure Insights

Hydrolysis/[3 + 2] cycloaddition/elimination cascades employed for the synthesis of unexpected tricyclic compound derived from isoquinoline. Reaction of ethylene derivative <b>1</b> with the isoquinoline ester iminium ion <b>2</b> in alkaline medium (MeOH/NEt<sub>3</...

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Bibliographic Details
Main Authors: Mezna Saleh Altowyan, Saied M. Soliman, Matti Haukka, Nora H. Al-Shaalan, Aminah A. Alkharboush, Assem Barakat
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Crystals
Subjects:
pyrrolo[2,1-<i>a</i>]isoquinoline
azomethine ylide
[3 + 2] cycloaddition (32CA) reaction
stereoselective
DFT
Hirshfeld
Online Access:https://www.mdpi.com/2073-4352/12/1/6

Internet

https://www.mdpi.com/2073-4352/12/1/6

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