Comprehensive analysis of oncogenic fusions in mismatch repair deficient colorectal carcinomas by sequential DNA and RNA next generation sequencing

Comprehensive analysis of oncogenic fusions in mismatch repair deficient colorectal carcinomas by sequential DNA and RNA next generation sequencing

Abstract Background Colorectal carcinoma (CRC) harboring oncogenic fusions has been reported to be highly enriched in mismatch repair deficient (dMMR) tumors with MLH1 hypermethylation (MLH1 me+) and wild-type BRAF and RAS. In this study, dMMR CRCs were screened for oncogene fusions using sequential...

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Bibliographic Details
Main Authors: Jing Wang, Ruiyu Li, Junjie Li, Yuting Yi, Xiaoding Liu, Jingci Chen, Hui Zhang, Junliang Lu, Cami Li, Huanwen Wu, Zhiyong Liang
Format: Article
Language:English
Published: BMC 2021-10-01
Series:Journal of Translational Medicine
Subjects:
Mismatch repair
Colorectal carcinoma
RNA next generation sequencing
Gene fusion
Online Access:https://doi.org/10.1186/s12967-021-03108-6

Internet

https://doi.org/10.1186/s12967-021-03108-6

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