MF59 Promoted the Combination of CpG ODN1826 and MUC1-MBP Vaccine-Induced Antitumor Activity Involved in the Enhancement of DC Maturation by Prolonging the Local Retention Time of Antigen and Down-Regulating of IL-6/STAT3

MF59 Promoted the Combination of CpG ODN1826 and MUC1-MBP Vaccine-Induced Antitumor Activity Involved in the Enhancement of DC Maturation by Prolonging the Local Retention Time of Antigen and Down-Regulating of IL-6/STAT3

Our previous study found that CpG oligodeoxynucleotides 1826 (CpG 1826), combined with mucin 1 (MUC1)-maltose-binding protein (MBP) (M-M), had certain antitumor activity. However, this combination is less than ideal for tumor suppression (tumors vary in size and vary widely among individuals), with...

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Bibliographic Details
Main Authors: Jing Jie, Guomu Liu, Jingyue Feng, Desheng Huo, Yixuan Wu, Hongyan Yuan, Guixiang Tai, Weihua Ni
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
MF59
CpG 1826
compound adjuvant
tumor vaccine
MUC1-MBP
dendritic cells
Online Access:https://www.mdpi.com/1422-0067/23/18/10887

Internet

https://www.mdpi.com/1422-0067/23/18/10887

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