Endothelial cilia dysfunction in pathogenesis of hereditary hemorrhagic telangiectasia

Endothelial cilia dysfunction in pathogenesis of hereditary hemorrhagic telangiectasia

Hereditary hemorrhagic telangiectasia (HHT) is associated with defective capillary network, leading to dilated superficial vessels and arteriovenous malformations (AVMs) in which arteries connect directly to the veins. Loss or haploinsufficiency of components of TGF-β signaling, ALK1, ENG, SMAD4, an...

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Bibliographic Details
Main Authors: Shahram Eisa-Beygi, Patricia E. Burrows, Brian A. Link
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Vascular disease
Zebrafish
TGF-β
Endothelial cilia
BMP signaling
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.1037453/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.1037453/full

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