Population pharmacokinetics and individualized dosing of vancomycin for critically ill patients receiving continuous renal replacement therapy: the role of residual diuresis

Population pharmacokinetics and individualized dosing of vancomycin for critically ill patients receiving continuous renal replacement therapy: the role of residual diuresis

Background: Vancomycin dosing is difficult in critically ill patients receiving continuous renal replacement therapy (CRRT). Previous population pharmacokinetic (PopPK) models seldom consider the effect of residual diuresis, a significant factor of elimination, and thus have poor external utility. T...

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Bibliographic Details
Main Authors: Zhenwei Yu, Jieqiong Liu, Haitao Yu, Ling Zhou, Jianping Zhu, Gang Liang, Yi Yang, Ying Zheng, Yun Han, Junjun Xu, Gang Han, Lingyan Yu, Yuhua Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Pharmacology
Subjects:
vancomycin
residual renal function
continuous renal replacement therapy
critically ill
population pharmacokinetics
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1298397/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1298397/full

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