ELA-11 protects the heart against oxidative stress injury induced apoptosis through ERK/MAPK and PI3K/AKT signaling pathways

ELA-11 protects the heart against oxidative stress injury induced apoptosis through ERK/MAPK and PI3K/AKT signaling pathways

Increasing evidence revealed that apoptosis and oxidative stress injury were associated with the pathophysiology of doxorubicin (DOX)-induced myocardial injury. ELABELA (ELA) is a newly identified peptide with 32 amino acids, can reduce hypertension with exogenous infusion. However, the effect of 11...

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Bibliographic Details
Main Authors: Xuejun Wang, Li Zhang, Mengwen Feng, Zhongqing Xu, Zijie Cheng, Lingmei Qian
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
ELA-11
doxorubicin
heart failure
apoptosis
oxidative stress
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.873614/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.873614/full

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