Exploring the putative role of PRDM1 and PRDM2 transcripts as mediators of T lymphocyte activation

Exploring the putative role of PRDM1 and PRDM2 transcripts as mediators of T lymphocyte activation

Abstract Background T cell activation and programming from their naïve/resting state, characterized by widespread modifications in chromatin accessibility triggering extensive changes in transcriptional programs, is orchestrated by several cytokines and transcription regulators. PRDM1 and PRDM2 enco...

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Bibliographic Details
Main Authors: Erika Di Zazzo, Monica Rienzo, Amelia Casamassimi, Caterina De Rosa, Nicola Medici, Patrizia Gazzerro, Maurizio Bifulco, Ciro Abbondanza
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Journal of Translational Medicine
Subjects:
PRDM1/BLIMP1
PRDM2/RIZ
T lymphocyte activation
T lymphocyte commitment
Transcription factors
Transcription regulation
Online Access:https://doi.org/10.1186/s12967-023-04066-x

Internet

https://doi.org/10.1186/s12967-023-04066-x

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