The FBXO32/ATR/ATM axis acts as a molecular switch to control the sensitivity of osteosarcoma cells to irradiation through its regulation of EXO1 expression

The FBXO32/ATR/ATM axis acts as a molecular switch to control the sensitivity of osteosarcoma cells to irradiation through its regulation of EXO1 expression

Osteosarcoma (OS) is the most common primary bone cancer in children and adolescents. In clinical treatments, the insensitivity of OS to conventional radiotherapy regimens significantly contributes to poor patient prognosis and survival. EXO1 is responsible for DNA repair pathways and telomere maint...

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Bibliographic Details
Main Authors: Lu Yao, Huang Panpan, Li Yanli, Liu Wenyu, Li Jing, Zhao Rui, Feng Haihua, Shi Ce, Cao Gaolu
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2023-05-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
osteosarcoma
EXO1
ATM
ATR
FBXO32
irradiation
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2023049

Internet

https://www.sciengine.com/doi/10.3724/abbs.2023049

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