Amyloid Precursor Protein Translation Is Regulated by a 3'UTR Guanine Quadruplex.

Amyloid Precursor Protein Translation Is Regulated by a 3'UTR Guanine Quadruplex.

A central event in Alzheimer's disease is the accumulation of amyloid β (Aβ) peptides generated by the proteolytic cleavage of the amyloid precursor protein (APP). APP overexpression leads to increased Aβ generation and Alzheimer's disease in humans and altered neuronal migration and incre...

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Bibliographic Details
Main Authors: Ezekiel Crenshaw, Brian P Leung, Chun Kit Kwok, Michal Sharoni, Kalee Olson, Neeraj P Sebastian, Sara Ansaloni, Reinhard Schweitzer-Stenner, Michael R Akins, Philip C Bevilacqua, Aleister J Saunders
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4664259?pdf=render

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http://europepmc.org/articles/PMC4664259?pdf=render

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