Nucleolar Essential Protein 1 (Nep1): Elucidation of enzymatic catalysis mechanism by molecular dynamics simulation and quantum mechanics study

Nucleolar Essential Protein 1 (Nep1): Elucidation of enzymatic catalysis mechanism by molecular dynamics simulation and quantum mechanics study

The Nep1 protein is essential for the formation of eukaryotic and archaeal small ribosomal subunits, and it catalyzes the site-directed SAM-dependent methylation of pseudouridine (Ψ) during pre-rRNA processing. It possesses a non–trivial topology, namely, a 31 knot in the active site. Here, we addre...

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Bibliographic Details
Main Authors: Mateusz Jedrzejewski, Barbara Belza, Iwona Lewandowska, Marta Sadlej, Agata P. Perlinska, Rafal Augustyniak, Thomas Christian, Ya-Ming Hou, Marcin Kalek, Joanna I. Sulkowska
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Nep1
Trefoil knot
RNA processing
Methylation
Proton transfer
Enzymatic catalysis
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037023002763

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http://www.sciencedirect.com/science/article/pii/S2001037023002763

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