Multivalent design of the monoclonal SynO2 antibody improves binding strength to soluble α-Synuclein aggregates

Multivalent design of the monoclonal SynO2 antibody improves binding strength to soluble α-Synuclein aggregates

ABSTRACTSoluble aggregates are reported to be the most neurotoxic species of α-Synuclein (αSyn) in Parkinson’s disease (PD) and hence are a promising target for diagnosis and treatment of PD. However, the predominantly intracellular location of αSyn limits its accessibility, especially for antibody-...

Full description

Bibliographic Details
Main Authors: Inga Petersen, Muhammad Ilyas Ali, Alex Petrovic, Anders Jimmy Ytterberg, Karin Staxäng, Monika Hodik, Fadi Rofo, Sina Bondza, Greta Hultqvist
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:mAbs
Subjects:
Avidity
multivalent antibodies
Parkinson’s disease (PD)
soluble aggregates
alpha-Synuclein (αsyn)
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2023.2256668

Internet

https://www.tandfonline.com/doi/10.1080/19420862.2023.2256668

Similar Items