Involvement of the TRPML Mucolipin Channels in Viral Infections and Anti-viral Innate Immune Responses

Involvement of the TRPML Mucolipin Channels in Viral Infections and Anti-viral Innate Immune Responses

The TRPML channels (TRPML1, TRPML2, and TRPML3), belonging to the mucolipin TRP subfamily, primary localize to a population of membrane-bonded vesicles along the endocytosis, and exocytosis pathways. Human viruses enter host cells by plasma membrane penetration or by receptor-mediated endocytosis. T...

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Bibliographic Details
Main Authors: Giorgio Santoni, Maria Beatrice Morelli, Consuelo Amantini, Massimo Nabissi, Matteo Santoni, Angela Santoni
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Immunology
Subjects:
TRP channel
mucolipin
innate immunity
viral infection
endolysosome
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00739/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00739/full

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