Mitochondrial and Endoplasmic Reticulum Stress Trigger Triglyceride Accumulation in Models of Parkinson’s Disease Independent of Mutations in MAPT

Mitochondrial and Endoplasmic Reticulum Stress Trigger Triglyceride Accumulation in Models of Parkinson’s Disease Independent of Mutations in MAPT

The metabolic basis of Parkinson’s disease pathology is poorly understood. However, the involvement of mitochondrial and endoplasmic reticulum stress in dopamine neurons in disease aetiology is well established. We looked at the effect of rotenone- and tunicamycin-induced mitochondrial and ER stress...

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Bibliographic Details
Main Authors: Hugo J. R. Fernandes, Josh P. Kent, Michaela Bruntraeger, Andrew R. Bassett, Albert Koulman, Emmanouil Metzakopian, Stuart G. Snowden
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Metabolites
Subjects:
metabolomics
Parkinson’s disease
triglyceride
LC-MS
mitochondrial stress
endoplasmic reticulum stress
Online Access:https://www.mdpi.com/2218-1989/13/1/112

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https://www.mdpi.com/2218-1989/13/1/112

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