Short-Term TERT Inhibition Impairs Cellular Proliferation via a Telomere Length-Independent Mechanism and Can Be Exploited as a Potential Anticancer Approach

Short-Term TERT Inhibition Impairs Cellular Proliferation via a Telomere Length-Independent Mechanism and Can Be Exploited as a Potential Anticancer Approach

Telomerase reverse transcriptase (TERT), the catalytic component of telomerase, may also contribute to carcinogenesis via telomere-length independent mechanisms. Our previous in vitro and in vivo studies demonstrated that short-term telomerase inhibition by BIBR1532 impairs cell proliferation withou...

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Bibliographic Details
Main Authors: Aamir Amin, Marzia Morello, Maria Raffaella Petrara, Beatrice Rizzo, Francesco Argenton, Anita De Rossi, Silvia Giunco
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Cancers
Subjects:
TERT/telomerase
TERT extra-telomeric functions
NF-kB p65
MYC
EBV-immortalized and fully transformed B cells
new therapeutic approach
Online Access:https://www.mdpi.com/2072-6694/15/10/2673

Internet

https://www.mdpi.com/2072-6694/15/10/2673

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