Glycosylation of recombinant adeno-associated virus serotype 6

Glycosylation of recombinant adeno-associated virus serotype 6

Glycosylation of biopharmaceuticals can affect their safety and efficacy. Glycans can occur on recombinant adeno-associated viruses (rAAVs) that are used for gene therapy; however, the types of glycans that attach to rAAVs are controversial. Here, we conducted lectin microarray analyses on six rAAV...

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Bibliographic Details
Main Authors: Yuki Yamaguchi, Kentaro Ishii, Sachiko Koizumi, Hiroaki Sakaue, Takahiro Maruno, Mitsuko Fukuhara, Risa Shibuya, Yasuo Tsunaka, Aoba Matsushita, Karin Bandoh, Tetsuo Torisu, Chie Murata-Kishimoto, Azusa Tomioka, Saho Mizukado, Hiroyuki Kaji, Yuji Kashiwakura, Tsukasa Ohmori, Atsushi Kuno, Susumu Uchiyama
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
gene therapy
adeno-associated virus
glycosylation
lectin microarray
liquid chromatography-tandem mass spectrometry
transduction efficiency
Online Access:http://www.sciencedirect.com/science/article/pii/S232905012400072X

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http://www.sciencedirect.com/science/article/pii/S232905012400072X

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