The Protective Effects of Ecdysterone on Cognitive Impairment through Regulating Akt/GSK-3β/Nrf2 Signaling Pathway and Oxidative Stress in Cognitive Mice Model and Aβ-Induced Cell Neurotoxicity

The Protective Effects of Ecdysterone on Cognitive Impairment through Regulating Akt/GSK-3β/Nrf2 Signaling Pathway and Oxidative Stress in Cognitive Mice Model and Aβ-Induced Cell Neurotoxicity

Background: Severe neurological condition like Alzheimer’s disease (AD) has a significantly negative impact on families and society, wherein there is no proven cure. As one of the principal active constituents of Achyranthes bidentata Blume, ecdysterone (ECR) has demonstrated antioxidant and cogniti...

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Bibliographic Details
Main Authors: Haihui Xing, Guohua Chen, Faisal Raza, Hajra Zafar, Lei Xing, Qiaoyun Li, Ran Li, Shanshan Xu, Dan Chen
Format: Article
Language:English
Published: IMR Press 2024-03-01
Series:Frontiers in Bioscience-Landmark
Subjects:
alzheimer's disease
ecdysterone
oxidative stress
nrf2
akt/gsk3β
Online Access:https://www.imrpress.com/journal/FBL/29/3/10.31083/j.fbl2903109

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https://www.imrpress.com/journal/FBL/29/3/10.31083/j.fbl2903109

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