A non-transcriptional function of Yap regulates the DNA replication program in Xenopus laevis

A non-transcriptional function of Yap regulates the DNA replication program in Xenopus laevis

In multicellular eukaryotic organisms, the initiation of DNA replication occurs asynchronously throughout S-phase according to a regulated replication timing program. Here, using Xenopus egg extracts, we showed that Yap (Yes-associated protein 1), a downstream effector of the Hippo signalling pathwa...

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Bibliographic Details
Main Authors: Rodrigo Meléndez García, Olivier Haccard, Albert Chesneau, Hemalatha Narassimprakash, Jérôme Roger, Muriel Perron, Kathrin Marheineke, Odile Bronchain
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-07-01
Series:eLife
Subjects:
hippo/yap pathway
Rif1
DNA replication
retinal stem cells
trim-away
Online Access:https://elifesciences.org/articles/75741

Internet

https://elifesciences.org/articles/75741

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