Overexpressed pigment epithelium-derived factor alleviates pulmonary hypertension in two rat models induced by monocrotaline and SU5416/hypoxia

Overexpressed pigment epithelium-derived factor alleviates pulmonary hypertension in two rat models induced by monocrotaline and SU5416/hypoxia

Background: Pulmonary hypertension (PH) is a progressive and fatal cardiopulmonary disease characterized by vascular remodeling and is associated with endothelial-to-mesenchymal transition (EndoMT). The pigment epithelium-derived factor (PEDF), a secretory protein widely distributed in multiple orga...

Full description

Bibliographic Details
Main Authors: Haoran Miao, Hongliang Hui, Wenbin Fan, Yangui Lin, Huaming Li, Dan Li, Min Luo, Fan Qiu, Bo Jiang, Yiqian Zhang
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Pigment epithelium-derived factor
Pulmonary hypertension
Vascular remodeling
Endothelial-to-mesenchymal transition
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332224001847

Internet

http://www.sciencedirect.com/science/article/pii/S0753332224001847

Similar Items