Diabetes Impairs Angiogenesis and Induces Endothelial Cell Senescence by Up-Regulating Thrombospondin-CD47-Dependent Signaling

Diabetes Impairs Angiogenesis and Induces Endothelial Cell Senescence by Up-Regulating Thrombospondin-CD47-Dependent Signaling

Endothelial dysfunction, impaired angiogenesis and cellular senescence in type 2 diabetes constitute dominant risk factors for chronic non-healing wounds and other cardiovascular disorders. Studying these phenomena in the context of diabetes and the TSP1-CD-47 signaling dictated the use of the in vi...

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Bibliographic Details
Main Author: Milad S. Bitar
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:International Journal of Molecular Sciences
Subjects:
endothelial dysfunction
impaired angiogenesis
diabetes
cellular senescence TSP1-CD47
oxidative stress.
Online Access:https://www.mdpi.com/1422-0067/20/3/673

Internet

https://www.mdpi.com/1422-0067/20/3/673

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