Diabetes-induced hepatic pathogenic damage, inflammation, oxidative stress, and insulin resistance was exacerbated in zinc deficient mouse model.

Zinc (Zn) deficiency often occurs in the patients with diabetes. Effects of Zn deficiency on diabetes-induced hepatic injury were investigated.Type 1 diabetes was induced in FVB mice with multiple low-dose streptozotocin. Hyperglycemic and age-matched control mice were treated with and without Zn ch...

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Bibliographic Details
Main Authors: Chi Zhang, Xuemian Lu, Yi Tan, Bing Li, Xiao Miao, Litai Jin, Xue Shi, Xiang Zhang, Lining Miao, Xiaokun Li, Lu Cai
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3520990?pdf=render