Common variants of TLR1 associate with organ dysfunction and sustained pro-inflammatory responses during sepsis.

Common variants of TLR1 associate with organ dysfunction and sustained pro-inflammatory responses during sepsis.

BACKGROUND: Toll-like receptors (TLRs) are critical components for host pathogen recognition and variants in genes participating in this response influence susceptibility to infections. Recently, TLR1 gene polymorphisms have been found correlated with whole blood hyper-inflammatory responses to path...

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Main Authors: Maria Pino-Yanes, Almudena Corrales, Milena Casula, Jesús Blanco, Arturo Muriel, Elena Espinosa, Miguel García-Bello, Antoni Torres, Miguel Ferrer, Elizabeth Zavala, Jesús Villar, Carlos Flores, GRECIA and GEN-SEP Groups
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2966434?pdf=render

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http://europepmc.org/articles/PMC2966434?pdf=render

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