YY1-induced upregulation of LncRNA-ARAP1-AS2 and ARAP1 promotes diabetic kidney fibrosis via aberrant glycolysis associated with EGFR/PKM2/HIF-1α pathway

YY1-induced upregulation of LncRNA-ARAP1-AS2 and ARAP1 promotes diabetic kidney fibrosis via aberrant glycolysis associated with EGFR/PKM2/HIF-1α pathway

Objectives: Dimeric pyruvate kinase (PK) M2 (PKM2) plays an important role in promoting the accumulation of hypoxia-inducible factor (HIF)-1α, mediating aberrant glycolysis and inducing fibrosis in diabetic kidney disease (DKD). The aim of this work was to dissect a novel regulatory mechanism of Yin...

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Main Authors: Xin Li, Tian-Kui Ma, Min Wang, Xiao-Dan Zhang, Tian-Yan Liu, Yue Liu, Zhao-Hui Huang, Yong-Hong Zhu, Shuang Zhang, Li Yin, Yan-Yan Xu, Hong Ding, Cong Liu, Hang Shi, Qiu-Ling Fan
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Pharmacology
Subjects:
LncRNA-ARAP1-AS2
ARAP1
diabetic kidney disease
HIF-1α
glycolysis
fibrosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1069348/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1069348/full

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