Inhibition of post-termination ribosome recycling at premature termination codons in UPF1 ATPase mutants

Inhibition of post-termination ribosome recycling at premature termination codons in UPF1 ATPase mutants

Recognition and rapid degradation of mRNA harboring premature translation termination codons (PTCs) serves to protect cells from accumulating non-functional and potentially toxic truncated polypeptides. Targeting of PTC-containing transcripts is mediated by the nonsense-mediated mRNA decay (NMD) pat...

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Bibliographic Details
Main Authors: Lucas D Serdar, DaJuan L Whiteside, Sarah L Nock, David McGrath, Kristian E Baker
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-07-01
Series:eLife
Subjects:
nonsense mediated decay
UPF1
translation
ribosome recycling
termination
Online Access:https://elifesciences.org/articles/57834

Internet

https://elifesciences.org/articles/57834

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