Loss of SOX18/CLAUDIN5 disrupts the pulmonary endothelial barrier in ventilator-induced lung injury

Loss of SOX18/CLAUDIN5 disrupts the pulmonary endothelial barrier in ventilator-induced lung injury

Mechanical strain contributes to ventilator-induced lung injury (VILI) through multi-factorial and complex mechanisms that remain unresolved. Prevailing evidence suggests that the loss of pulmonary endothelial tight junctions (TJs) plays a critical role. TJs are dynamically regulated by physiologic...

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Bibliographic Details
Main Authors: Alejandro E. Garcia-Flores, Christine M. Gross, Evgeny A. Zemskov, Qing Lu, Kim Tieu, Ting Wang, Stephen M. Black
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Physiology
Subjects:
mechanical stress
SOX-18
claudin-5
ALI
endothelial barrier function
tight junctions
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.1066515/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2022.1066515/full

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