In Vitro, In Vivo and In Silico Characterization of a Novel Kappa-Opioid Receptor Antagonist

In Vitro, In Vivo and In Silico Characterization of a Novel Kappa-Opioid Receptor Antagonist

Kappa-opioid receptor (KOR) antagonists are promising innovative therapeutics for the treatment of the central nervous system (CNS) disorders. The new scaffold opioid ligand, Compound A, was originally found as a mu-opioid receptor (MOR) antagonist but its binding/selectivity and activation profile...

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Bibliographic Details
Main Authors: Kristina Puls, Aina-Leonor Olivé-Marti, Szymon Pach, Birgit Pinter, Filippo Erli, Gerhard Wolber, Mariana Spetea
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Pharmaceuticals
Subjects:
GPCRs
kappa-opioid receptor
antagonists
binding affinity
selectivity
in vivo antagonism
Online Access:https://www.mdpi.com/1424-8247/15/6/680

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https://www.mdpi.com/1424-8247/15/6/680

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