Loss of SLC26A3 Results in Colonic Mucosal Immune Dysregulation via Epithelial-Immune Cell Crosstalk

Loss of SLC26A3 Results in Colonic Mucosal Immune Dysregulation via Epithelial-Immune Cell Crosstalk

Background & Aims: Down-regulation of chloride transporter SLC26A3 or down-regulated in adenoma (DRA) in colonocytes has recently been linked to the pathogenesis of ulcerative colitis (UC). Because exaggerated immune responses are one of the hallmarks of UC, these current studies were undert...

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Bibliographic Details
Main Authors: Dulari Jayawardena, Shubha Priyamvada, Takahiro Kageyama, Zachary White, Anoop Kumar, Theodor F. Griggs, Apurba Majumder, Ramsha Akram, Arivarasu N. Anbazhagan, Teruyuki Sano, Pradeep K. Dudeja
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
Down Regulated in Adenoma
Type 2 Innate Lymphoid Cells
Regulatory T-cells
Ulcerative Colitis
GATA3
Interleukin-33
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X22002570

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http://www.sciencedirect.com/science/article/pii/S2352345X22002570

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