Lipid Metabolic Pathways Confer the Immunosuppressive Function of Myeloid-Derived Suppressor Cells in Tumor

Lipid Metabolic Pathways Confer the Immunosuppressive Function of Myeloid-Derived Suppressor Cells in Tumor

Myeloid-derived suppressor cells (MDSCs) play crucial roles in tumorigenesis and their inhibition is critical for successful cancer immunotherapy. MDSCs undergo metabolic reprogramming from glycolysis to fatty acid oxidation (FAO) and oxidative phosphorylation led by lipid accumulation in tumor. Inc...

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Bibliographic Details
Main Authors: Dehong Yan, Adeleye O. Adeshakin, Meichen Xu, Lukman O. Afolabi, Guizhong Zhang, Youhai H. Chen, Xiaochun Wan
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Immunology
Subjects:
MDSCs
lipid metabolism
FAO-OXPHOS
immunosuppressive
cancer immunotherapy
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01399/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01399/full

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