Differential LRRK2 Signalling and Gene Expression in WT-LRRK2 and G2019S-LRRK2 Mouse Microglia Treated with Zymosan and MLi2

Differential LRRK2 Signalling and Gene Expression in WT-LRRK2 and G2019S-LRRK2 Mouse Microglia Treated with Zymosan and MLi2

Mutations in the leucine-rich repeat kinase 2 (<i>LRRK2</i>) gene cause autosomal dominant Parkinson’s disease (PD), with the most common causative mutation being the <i>LRRK2</i> p.G2019S within the kinase domain. LRRK2 protein is highly expressed in the human brain and also...

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Bibliographic Details
Main Authors: Iqra Nazish, Adamantios Mamais, Anna Mallach, Conceicao Bettencourt, Alice Kaganovich, Thomas Warner, John Hardy, Patrick A. Lewis, Jennifer Pocock, Mark R. Cookson, Rina Bandopadhyay
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Cells
Subjects:
<i>LRRK2</i>
TLR2
LRRK2 p.G2019S knock-in
zymosan
MLi.2
RNA-Seq
Online Access:https://www.mdpi.com/2073-4409/13/1/53

Internet

https://www.mdpi.com/2073-4409/13/1/53

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