Single-cell atlas of keratoconus corneas revealed aberrant transcriptional signatures and implicated mechanical stretch as a trigger for keratoconus pathogenesis

Single-cell atlas of keratoconus corneas revealed aberrant transcriptional signatures and implicated mechanical stretch as a trigger for keratoconus pathogenesis

Abstract Keratoconus is a common ectatic corneal disorder in adolescents and young adults that can lead to progressive visual impairment or even legal blindness. Despite the high prevalence, its etiology is not fully understood. In this study, we performed single-cell RNA sequencing (scRNA-Seq) anal...

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Bibliographic Details
Main Authors: Shengqian Dou, Qun Wang, Bin Zhang, Chao Wei, Huijin Wang, Ting Liu, Haoyun Duan, Hui Jiang, Mingna Liu, Xiaolin Qi, Qingjun Zhou, Lixin Xie, Weiyun Shi, Hua Gao
Format: Article
Language:English
Published: Nature Publishing Group 2022-07-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-022-00397-z

Internet

https://doi.org/10.1038/s41421-022-00397-z

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