Topiramate alters the gut microbiome to aid in its anti-seizure effect

IntroductionThere is a growing interest in the role of the gut microbiota in epilepsy, however, it is unclear if anti-seizure medications (ASMs) play a role in the gut-brain axis. To test this, we investigated the impact of the ASM topiramate on the gut microbiome of mice.MethodsC57BL/6J mice were a...

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Bibliographic Details
Main Authors: K'Ehleyr Thai, Michael W. Taylor, Tatiane Fernandes, Eunice A. Akinade, Susan L. Campbell
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Microbiology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2023.1242856/full