Total Coumarins from Hydrangea paniculata Show Renal Protective Effects in Lipopolysaccharide-Induced Acute Kidney Injury via Anti-inflammatory and Antioxidant Activities

Total Coumarins from Hydrangea paniculata Show Renal Protective Effects in Lipopolysaccharide-Induced Acute Kidney Injury via Anti-inflammatory and Antioxidant Activities

Background: Septic acute kidney injury (AKI) causes high mortality in critical care units, and no effective therapy exists in clinical treatment. In the current study, water and ethanol extracts of Hydrangea paniculata (HP), a traditional Chinese medicinal plant, were used to test its renoprotective...

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Bibliographic Details
Main Authors: Sen Zhang, Jie Ma, Li Sheng, Dongming Zhang, Xiaoguang Chen, Jingzhi Yang, Dongjie Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Pharmacology
Subjects:
sepsis
acute kidney injury
coumarin
H. paniculata
pharmacokinetics
anti-inflammation
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00872/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00872/full

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