Recombinant BCG With Bacterial Signaling Molecule Cyclic di-AMP as Endogenous Adjuvant Induces Elevated Immune Responses After Mycobacterium tuberculosis Infection

Recombinant BCG With Bacterial Signaling Molecule Cyclic di-AMP as Endogenous Adjuvant Induces Elevated Immune Responses After Mycobacterium tuberculosis Infection

Bacillus Calmette-Guerin (BCG) is a live attenuated vaccine against tuberculosis (TB) and remains the most commonly used vaccine worldwide. However, BCG has varied protective efficiency in adults and has safety concerns in immunocompromised population. Thus, effective vaccines are necessary for prev...

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Bibliographic Details
Main Authors: Huanhuan Ning, Lifei Wang, Jie Zhou, Yanzhi Lu, Jian Kang, Tianbing Ding, Lixin Shen, Zhikai Xu, Yinlan Bai
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Immunology
Subjects:
Mycobacterium tuberculosis
recombinant BCG
cyclic di-AMP
adjuvant
immune response
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01519/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01519/full

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